DENOISING ALGORITHM FOR THE PIXEL-RESPONSE NON-UNIFORMITY CORRECTION OF A SCIENTIFIC CMOS UNDER LOW LIGHT CONDITIONS

Abstract. We present a denoising algorithm for the pixel-response non-uniformity correction of a scientific complementary metal–oxide–semiconductor (CMOS) image sensor, which captures images under extremely low-light conditions. By analyzing the integrating sphere experimental data, we present a pixel-by-pixel flat-field denoising algorithm to remove this fixed pattern noise, which occur in low-light conditions and high pixel response readouts. The response of the CMOS image sensor imaging system to the uniform radiance field shows a high level of spatial uniformity after the denoising algorithm has been applied.