In the process of object-oriented change detection, the determination of the optimal segmentation scale is directly related to the subsequent change information extraction and analysis. Aiming at this problem, this paper presents a novel object-level change detection method based on multi-scale segmentation and fusion. First of all, the fine to coarse segmentation is used to obtain initial objects of different sizes; then, according to the features of the objects, Change Vector Analysis is used to obtain the change detection results of various scales. Furthermore, in order to improve the accuracy of change detection, this paper introduces fuzzy fusion and two kinds of decision level fusion methods to get the results of multi-scale fusion. Based on these methods, experiments are done with SPOT5 multi-spectral remote sensing imagery. Compared with pixel-level change detection methods, the overall accuracy of our method has been improved by nearly 10%, and the experimental results prove the feasibility and effectiveness of the fusion strategies.