The church dedicated to Sant'Andrea (St. Andrew) in <q>Porta Dipinta</q> street in Bergamo city is a treasure that keep inside it a rich heritage of great historical and cultural value, both from the architectural and from the artistic point of view. Lacking of the façade (left unfinished), it is often neglected, despite being on the main road leading to the old town from <q>Sant'Agostino</q> Gate. The approach to an historical building like this requires a multi-disciplinary integration, in order to join the technical competence of engineering sciences to the sensitivity of human and fine arts sciences. For a better understanding of the structural performances of the building, historical research, measurement survey, material and decay condition study have to complement each other.