The increase in drug use worldwide has led to sophisticated illegal planting methods. Most countries depend on helicopters, and local knowledge to identify such illegal plantations. However, remote sensing techniques can provide special advantages for monitoring the extent of illegal drug production. This paper sought to assess the ability of the Satellite remote sensing to detect Cannabis plantations. This was achieved in two stages: 1- Preprocessing of Hyperspectral data EO-1, and testing the capability to collect the spectral signature of Cannabis in different sites of the study area (Morocco) from well-known Cannabis plantation fields. 2- Applying the method of Spectral Angle Mapper (SAM) based on a specific angle threshold on Hyperion data EO-1 in well-known Cannabis plantation sites, and other sites with negative Cannabis plantation in another study area (Algeria), to avoid any false Cannabis detection using these spectra. This study emphasizes the benefits of using hyperspectral remote sensing data as an effective detection tool for illegal Cannabis plantation in inaccessible areas based on SAM classification method with a maximum angle (radians) less than 0.03.