In order to improve the efficiency of large scale orthophoto production of city, this paper presents a method for automatic selection of seamlines network in large scale orthophoto based on the buildings’ vector. Firstly, a simple model of the building is built by combining building’s vector, height and DEM, and the imaging area of the building on single DOM is obtained. Then, the initial Voronoi network of the measurement area is automatically generated based on the positions of the bottom of all images. Finally, the final seamlines network is obtained by optimizing all nodes and seamlines in the network automatically based on the imaging areas of the buildings. The experimental results show that the proposed method can not only get around the building seamlines network quickly, but also remain the Voronoi network’ characteristics of projection distortion minimum theory, which can solve the problem of automatic selection of orthophoto seamlines network in image mosaicking effectively.