Digitization of complex Cultural Heritage sites requires the integration of several strategies to achieve a comprehensive description of the site. This is the case of the digitization project of the Appian Way in Rome involving a section of 12 km from Capo di Bove to Frattocchie under the superintendence of the Parco Archeologico dell’Appia Antica. This paper presents some first results of the project with a specific focus on the acquisition of the primary data needed for the further steps of the project. In particular, the paper discusses the integration of different sensors such as lidar-based Mobile Mapping Systems, spheric (360°) cameras and digital (frame) calibrated cameras, for the reconstruction of point clouds to be used as input data for the digitization process. A specific attention is paid both on acquisition speed and to accuracy of the obtained results. The paper presents also some results showing the transformation of the acquired data into a GIS system to be used as a support tool for decision making of the public administration.