This study investigates the spatiotemporal variability of the aerosol optical depth (AOD) in the atmosphere over the Marmara region, Turkiye. Long-term satellite observations from MODIS MAIAC AOD data spanning the period from 2000 to 2021 are utilized. Examining the temporal variations in AOD in the Marmara region, it is observed that AOD reaches its peak during spring (May) and summer (August) months, while lower AOD values are observed in winter. Specifically, between August and December, there is a significant decline in monthly mean AOD which is majorly due to particulate removal from the atmosphere via precipitation scavenging. The findings reveal that the inter-annual variability of monthly AOD variations in the Marmara region is primarily influenced by temporary Saharan dust transportation with highest deviations from 22 year averaged AOD in late winters and early springs. The findings from the analysis of seasonal spatial variation of high AOD values revealed that the high AOD area is largest in the summer with about 54% of the total area and then spring (45%) and autumn (26%). Winter has the lowest HVA with 17% of the total area. The seasonal percentage rates of HVA are due to atmospheric conditions and aerosol sources. Larger HVA in summer is due to the increase of farming practices and biomass residue burnings combined with high moisture absorption effects and high temperature. The heating-specific emissions are the main source of anthropogenic emissions over the high AOD areas during the autumn and winter and aerosols are concentrated over the urbanized centres and industrialized zones.